Acne is a significant aspect of teenage life, but if it persists beyond the teenage years, it can lead to concern. In this article, we will explore two important brands, Differin and PanOxyl, which are well-known competitors in the over-the-counter skincare industry..
We will cover the key ingredients, usage, dosage, pros, cons, effectiveness, and much more about these two brand products. We will also find out which one is best for your skin.
So, without further ado, let’s get started!
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Quick Overview: Differin Vs PanOxyl
Feature | Differin (Adapalene 0.1%) | PanOxyl (Benzoyl Peroxide 4% or 10%) |
---|---|---|
Main Ingredient | Adapalene (a retinoid) | Benzoyl Peroxide |
How It Works | Regulates skin cell turnover, prevents clogged pores, reduces inflammation | Kills acne-causing bacteria, removes excess oil, reduces redness |
Best For | Blackheads, whiteheads, mild to moderate acne, long-term acne prevention | Inflamed acne (papules, pustules), oily skin, quick acne relief |
Application | Once daily at night | Once or twice daily |
Common Side Effects | Dryness, irritation, purging in the first few weeks | Dryness, irritation, possible bleaching of fabrics |
Time to See Results | 4-6 weeks for noticeable improvement | 1-2 weeks for reduced breakouts |
Sun Sensitivity | Increases skin sensitivity to the sun; sunscreen is essential | Can cause mild sun sensitivity; sunscreen recommended |
Can Be Used Together? | Yes, but not at the same time (Differin at night, PanOxyl in the morning) | Yes, but should not be applied together to avoid irritation |
What are Differin and PanOxyl?

Before comparing individual items, it is critical to grasp the primary distinctions between these two brands.
Adapalene, a retinoid included in Differin, helps treat acne by avoiding blocked pores and lowering inflammation. Blackheads and whiteheads (comedonal acne) respond well to it.
Benzoyl peroxide, a potent component in PanOxyl, eliminates excess oil and destroys germs that cause acne. It works particularly well for inflammatory acne, which includes papules and pustules, which are red, swollen pimples.
Both products are excellent for acne control, but it is important to select which one is best according to skin type.
Key Ingredients: Differin vs. PanOxyl
How to Use Differin (Adapalene) Safely:
- ✔ Apply to clean, dry skin once a day at night.
- ✔ To avoid irritation, apply a pea-sized quantity to the whole face.
- ✔ Avoid application near the eyes, lips, or damaged skin.
- ✔ If your skin is sensitive, begin gradually (every other night).
- ✔ Apply sunscreen every day since Differin may increase skin sensitivity to sunlight.
- ✔ In the first few weeks, anticipate a brief breakout or first purging.
How to Use PanOxyl (Benzoyl Peroxide) Safely:
- ✔ If your skin is sensitive, start with a lesser dose (4% or 5%).
- ✔ To avoid extreme dryness, use once a day or every other day.
- ✔ Avoid the mouth and eyes and apply a thin coating to the afflicted regions.
- ✔ Leave it on for 1-2 minutes before washing off (for face washes).
- ✔ Moisturize carefully after application, since benzoyl peroxide may be drying.
- ✔To avoid irritation, do not combine with Differin at the same time.
- ✔If taking both, use PanOxyl in the morning and Differin at night.
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Scent: Differin Vs PanOxyl
The scent of Differin Deep Cleanser is mild or almost negligible. If you are one of those who are allergic to or do not like strong scents, this could be a great option for you.
On the other hand, the scent of PanOxyl Acne Foaming Wash is somewhat medicinal and chlorine-like due to the benzoyl peroxide. It is not very harsh but smells like medicine.
For those who prefer completely mild or no fragrance, it might be a bit of a problem.
How to Use Differin and PanOxyl Safely?

The correct way to use Differin Cleanser is to first lightly wet your face. Then take a little cleanser in your hands and gently massage it onto your face in circular motions, especially in areas where there is acne or excess oil. Do not rub too harshly, just apply it well for 20-30 seconds.
After that, rinse your face with normal or slightly lukewarm water and gently pat dry (do not rub your face with a towel). Then it is important to apply a good moisturizer to keep the skin hydrated. For best results, use it twice a day.
Similarly, apply PanOxyl Acne Foaming Wash on a wet face, but leave it on for 5-8 minutes before washing your face. And use it twice a day. Don’t forget to apply sunscreen during the day, as benzoyl peroxide can make the skin a bit sensitive.
Differin Products and Their Benefits
1. The Gold Standard for Acne: Differin Gel (Adapalene 0.1%)
Its actions include:
- ✅ Unclogging pores and preventing breakouts
- ✅ Reducing inflammation and redness
- ✅ Improving skin tone and texture
How to use: Once a day at night, apply a pea-sized quantity to your whole face.
What to expect:
- During the first several weeks, it’s natural to feel a little dry and irritated.
- After eight to twelve weeks, acne begins to go away and skin texture improves.
Pro Tip: When taking Differin, always use sunscreen and moisturizer!
🔗 Buy Differin Gel
2. Daily Deep Cleanser by Differin (5% benzoyl peroxide)
A lot of people are unaware that Differin also sells a cleanser that contains 5% benzoyl peroxide.
What it does:
- ✅ Eliminates germs that cause acne
- ✅ aids in oil reduction and shine
- ✅ Sufficiently mild for everyday usage
To use, lightly massage a tiny quantity over moist skin, then rinse.
Who’s supposed to use this?
- This cleanser is an excellent morning choice if you use Differin Gel.
- This may be used in conjunction with adapalene treatments if your acne is moderate to severe.
PanOxyl Products and Their Benefits
1. PanOxyl Acne Foaming Wash (Benzoyl Peroxide 10%)
Its actions comprise:
- ✅ Eliminating 99% of germs that cause acne
- ✅ Deep cleaning pores and reducing excess oil
- ✅ Quick effects, with improvement possible in 1-4 weeks
How to apply:
- Use once daily at first, then twice daily if tolerated.
- Apply to wet skin, gently massage, and then rinse.
Warning signs:
- ♠ May result in dryness – Always apply a moisturizer after.
- ♠️ Able to bleach textiles – Use caution while handling pillows and towels!
2. PanOxyl Adapalene Gel 0.1%
What it does:
- It functions similarly to Differin Gel (using the same active ingredient, adapalene 0.1%) and helps with blocked pores, blackheads, and whiteheads.
Who’s supposed to use this?
- If you’re looking for a less expensive substitute for Differin.
- If you want a retinoid therapy that works.
Efficacy: PanOxyl vs Differin
Acne may be effectively treated with Differin and PanOxyl, however, they function differently. Differin (adapalene) is a retinoid that is perfect for blackheads, whiteheads, and mild to moderate acne since it helps prevent blocked pores, decrease inflammation, and stimulate skin cell turnover. Although obvious improvements take a few weeks to manifest, it aids in the long-term prevention of acne.
Conversely, PanOxyl (benzoyl peroxide) is a potent antibacterial agent that gets rid of acne-causing bacteria, gets rid of extra oil, and gets rid of redness and swelling. When it comes to inflamed acne, including papules and pustules, it acts fast. It could, however, irritate and dry up skin, particularly sensitive skin.
Your acne type will determine which of these is best for you: PanOxyl for immediate relief from inflammatory outbreaks, Differin for preventive and long-term care. For best results, some dermatologists advise combining the two in a daily regimen.
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Professional Opinions: Differin Vs Jergens
For the treatment of acne, dermatologists often suggest both benzoyl peroxide and adapalene. Adapalene helps exfoliate the skin to get rid of old skin cells and provide space for new ones to grow by increasing skin cell turnover. Benzoyl peroxide is utilized in treatments aimed at long-term skin clarity and is useful in treating obstinate acne.
Source: CURISTRELIEF.COM
User Experiences
Consumers’ experiences with Differin and PanOxyl products have been mixed. Benzoyl peroxide’s antibacterial qualities have helped some people, while adapalene’s anti-aging qualities have helped others. Individual skin types and concerns must be taken into account when selecting a product.
Source: CURISTRELIEF.COM
Price and Availability
Product | Price Range (USD) | Availability in India |
---|---|---|
Differin | $12 – $15 for 0.5 oz (15g) gel | Not widely available; may require international purchase |
PanOxyl | $9 – $12 for 5.5 oz (156g) foaming wash | Available through select online retailers, Style Dotty |
Side Effects: What Should You Watch Out For?
💢 Common Side Effects of Differin
- There may be purging for the first few weeks (more acne will be visible). Dryness and peeling may occur. Sun sensitivity may increase, so be sure to apply sunscreen.
🔥 Common Side Effects of PanOxyl
- The high-strength (10%) version can make the skin very dry and red. Those with sensitive skin should use the lower strength (4%). Overuse can irritate.
Which is Best for You? My Recommendation

- If your skin is sensitive or you have light acne, then Differin cleanser is the best option. And if your skin is oily or acne-prone, then PanOxyl will be better.
- If you are price-conscious, then PanOxyl might be a better option for you, because it is cost-effective.
- If you want immediate results, then Differin will be the right choice.
- If you want to clean acne from within, then PanOxyl is the best option.
Now the choice is yours, choose the product keeping your concerns and skin in mind.
Professional Advice on Using PanOxyl and Differin
- ✅ Start Slow: Before increasing the frequency, use these items every other day.
- ✅ Hydrate Well: Your skin may get parched after either treatment.
- ✅ Always use sunscreen since benzoyl peroxide and retinoid make your skin more vulnerable to the sun.
- ✅ Have patience: Acne remedies need time. Maintain a schedule for a minimum of eight to twelve weeks.
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FAQ’s About Differin Vs PanOxyl
Indeed! Numerous dermatologists advise using both:
1. To eradicate germs, use PanOxyl cleanser first thing in the morning.
2. To clear pores and avoid breakouts, use Differin Gel at night.
1. In one to four weeks, PanOxyl (Benzoyl Peroxide) may start to show results.
2. Although it takes 8–12 weeks, Differin (adapalene) has long-lasting effects.
Yes, but begin gradually and use a mild moisturizer such as La Roche-Posay Toleriane Double Repair or CeraVe PM.
Conclusion
As you read above, both products are effective in treating acne. It is important to choose a product keeping your skin concern in mind. If your skin is dry, use Differin Cleanser, and if it is oily, you can try PanOxyl Foaming Wash.
One important thing to keep in mind is that regardless of the product, consistency and patience are very important in skincare. If you keep changing products, you will never see results. So, be consistent.
If you liked the article, do share it with your friends who are struggling with acne so that they can get help.
Thanks for reading!

Sophie is your go-to girl for all things makeup and hair! She believes beauty should be fun, not stressful, and she’s here to share tips, product reviews, and honest thoughts from a real-world perspective.
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